This invited talk will describe the current landscape of CDISC initiatives and collaborations. CDISC currently has a portfolio of innovative industry initiatives that include new standards as well as open-source software projects that are part of the CDISC Open-Source Alliance (COSA). This talk will highlight many of the innovative initiatives reshaping standards-based data flows including transparent and metadata rich JSON transfer files, biomedical concepts, conformance rules, study design, analysis results standards, and RWD.