Metrum Research Group

yspec: an R Package to Create and Deploy Data Set Specification Objects in a Modeling and Simulation Workflow

A PK & PBPK Modelling Workflow in R: Simulation, Optimization & Visualization

After a brief introduction to mrgsolve (https//mrgsolve.github.io), we will discuss concepts and applications for using the package in R to simulate from pharmacokinetic (PK) and physiologically-based PK (PBPK) models, estimate parameters given a …

Prediction of maternal-fetal exposures of CYP450-metabolized drugs using physiologic pharmacokinetic modeling implemented in R and mrgsolve

Physiologically based pharmacokinetic (PBPK) models are used extensively in drug development to address of number of problems. However, most PBPK applications have limited knowledge sharing impact because they are implemented in closed, proprietary …

Leveraging multiple R tools to make effective pediatric dosing decisions

R Shiny apps allow for dynamic, interactive, real-time integration of knowledge within a drug-development program to support decision making. Here, an R Shiny app was used to explore the pharmacokinetic and pharmacodynamic effects of different dosing …

Package management

Unfortunately we do not currently have an abstract, copy of the slides or link to the video to this presentation

Assisting pharmacometric simulation with the use of Shiny

During the drug development, pharmacometric models are often built to characterize and understand drug efficacy and safety. Simulations based on these models can assist drug development and quantitative decision making. However, computation can be …

Moving Fast Without Breaking Things: Navigating the R Ecosystem in an Enterprise Environment

Despite the explosive growth and adoption of R globally, concerns over how to qualify and administrate R continues to echo in discussions about use in regulated environments. In this talk, I'll discuss the how to bridge the conceptual tenants of …

R as the Core Technology to Support Modeling and Simulation in Pharma Research, Development, and Post Approval Activities

Since its foundation in 2004, Metrum Research Group has relied on R as the core technology and central framework for all of the company’s biomedical modeling and simulation (M&S) service activities, spanning more than 475 projects with 150+ different …

Moving Fast Without Breaking Things: Navigating the R Ecosystem in an Enterprise Environment

Unfortunately we do not currently have an abstract, copy of the slides or link to the video to this presentation

The Use of R in the Development of Physiological Model for Healthy Growth

A physiologically-based mathematical model was developed as a series of ordinary differential equations to describe compositional changes (in fat and fat-free mass, FM & FFM) due to metabolizable energy exchanges in babies from birth to 2 years in …