Metrum Research Group (MetrumRG) has developed a suite of open-source R packages for pharmacometric analyses that can be used independently, or seamlessly integrated into a larger R-based ecosystem. To showcase this ecosystem, we used the popular …
After a brief introduction to mrgsolve (https//mrgsolve.github.io), we will discuss concepts and applications for using the package in R to simulate from pharmacokinetic (PK) and physiologically-based PK (PBPK) models, estimate parameters given a …
Physiologically based pharmacokinetic (PBPK) models are used extensively in drug development to address of number of problems. However, most PBPK applications have limited knowledge sharing impact because they are implemented in closed, proprietary …
R Shiny apps allow for dynamic, interactive, real-time integration of knowledge within a drug-development program to support decision making. Here, an R Shiny app was used to explore the pharmacokinetic and pharmacodynamic effects of different dosing …
During the drug development, pharmacometric models are often built to characterize and understand drug efficacy and safety. Simulations based on these models can assist drug development and quantitative decision making. However, computation can be …
Despite the explosive growth and adoption of R globally, concerns over how to qualify and administrate R continues to echo in discussions about use in regulated environments. In this talk, I'll discuss the how to bridge the conceptual tenants of …
Since its foundation in 2004, Metrum Research Group has relied on R as the core technology and central framework for all of the company’s biomedical modeling and simulation (M&S) service activities, spanning more than 475 projects with 150+ different …