This presentation provides an insightful exploration of GSK’s innovative journey in integrating Large Language Models (LLMs) into biostatistics. It begins with the strategic introduction of LLMs to users, progressing through to the pioneering LLM experiments aimed at automating our reporting pipeline. We will delve into the crucial considerations for successfully introducing LLMs to a biostatistics audience, sharing key insights learned from our experience. The presentation culminates with a forward-looking discussion on the evolving roles within the organization as the use of LLMs expands, highlighting GSK’s commitment to embracing change and leading the way in technological advancements.