Merck

ModViz POP: R-Shiny Based PK/PD Interface for Empowering Teams to Perform Real-Time Simulations

Objectives Demonstrate an interactive and dynamic visualization tool, ModViz POP, for simulating ordinary differential equations based PK/PD models with variability. Methods ModViz POP has an in built PKPD ODE library of models based on the …

Using R to foster the communication with non-statisticians on Bayesian dose escalation models

Bayesian model-based dose-escalation designs, including one and two parameter logistic regression models, have meanwhile proven themselves in Phase I dose-escalation trials (Iasonos and O'Quigley, 2014 [1]). Compared to rule/algorithm-based designs …

Teaching an old dog new tricks: modernizing gsDesign

The gsDesign package for group sequential design is widely used with 30k downloads. The package was originally written in 2007 with substantial documentation and Runit testing created before 2010. A Shiny interface was created to make the package …

Managing R and Associated Tools in Large Environments - an R-Admin’s Perspective

The dramatic increase of R in the computational, analytics, and data science areas has led to some innovative techniques in recent years for interactive analytics. This rate of change presents challenges for IT organizations to keep up and to …