Computationally-intensive workflows exist in the design, analysis, and simulation in all phases of clinical studies. The runtime of such workflows can be significantly longer than a Shiny app can practicably handle. In such situations, binding the …
In this talk, we will discuss an infrastructure-free R package exchange and distribution system. The components include pkglite for compact package representations, cleanslate for portable R environments, and pkglink for runtime dependency …
In the safety analysis of clinical trials, the forest plot plays an important role. Currently, most of the forest plots are static, which makes them non-reader-friendly to Data Monitoring Committee (DMC). In this project, we propose an R package - …
The use of open-source R is evolving in drug discovery, research and development for study design, data analysis, visualization, and report generation in the pharmaceutical industry. The ability to produce tables, listings and figures (TLFs) in …
Introduction to the X-Omics Platform (XOP), a digital biomarker research platform for bioinformaticians and other scientist at Merck KGaA. XOP is a validated system for storing, processing, and analyzing "omics" data, including RNASeq, DNASeq …
Start browsing through R tutorials online and it won't take long to stumble across a read.csv statement. CSV files serve well for detached, static analyses. They tend fail, however, when tasked with storing large, dynamic data sets being accessed …
Objectives Demonstrate an interactive and dynamic visualization tool, ModViz POP, for simulating ordinary differential equations based PK/PD models with variability. Methods ModViz POP has an in built PKPD ODE library of models based on the …
Bayesian model-based dose-escalation designs, including one and two parameter logistic regression models, have meanwhile proven themselves in Phase I dose-escalation trials (Iasonos and O'Quigley, 2014 [1]). Compared to rule/algorithm-based designs …