Merck

r2rtf - a Lightweight R Package to Produce Tables and Figures in RTF Format

The use of open-source R is evolving in drug discovery, research and development for study design, data analysis, visualization, and report generation in the pharmaceutical industry. The ability to produce tables, listings and figures (TLFs) in …

X-Omics Platform

Introduction to the X-Omics Platform (XOP), a digital biomarker research platform for bioinformaticians and other scientist at Merck KGaA. XOP is a validated system for storing, processing, and analyzing "omics" data, including RNASeq, DNASeq …

Its Not Whats on the Outside, but Its Whats on the Back-end That Matters: The World Beyond CSV Files

Start browsing through R tutorials online and it won't take long to stumble across a read.csv statement. CSV files serve well for detached, static analyses. They tend fail, however, when tasked with storing large, dynamic data sets being accessed …

ModViz POP: R-Shiny Based PK/PD Interface for Empowering Teams to Perform Real-Time Simulations

Objectives Demonstrate an interactive and dynamic visualization tool, ModViz POP, for simulating ordinary differential equations based PK/PD models with variability. Methods ModViz POP has an in built PKPD ODE library of models based on the …

Using R to foster the communication with non-statisticians on Bayesian dose escalation models

Bayesian model-based dose-escalation designs, including one and two parameter logistic regression models, have meanwhile proven themselves in Phase I dose-escalation trials (Iasonos and O'Quigley, 2014 [1]). Compared to rule/algorithm-based designs …

Teaching an old dog new tricks: modernizing gsDesign

The gsDesign package for group sequential design is widely used with 30k downloads. The package was originally written in 2007 with substantial documentation and Runit testing created before 2010. A Shiny interface was created to make the package …

Managing R and Associated Tools in Large Environments - an R-Admin’s Perspective

The dramatic increase of R in the computational, analytics, and data science areas has led to some innovative techniques in recent years for interactive analytics. This rate of change presents challenges for IT organizations to keep up and to …