Bayesian model-based dose-escalation designs, including one and two parameter logistic regression models, have meanwhile proven themselves in Phase I dose-escalation trials (Iasonos and O'Quigley, 2014 [1]). Compared to rule/algorithm-based designs …
The gsDesign package for group sequential design is widely used with 30k downloads. The package was originally written in 2007 with substantial documentation and Runit testing created before 2010. A Shiny interface was created to make the package …
The dramatic increase of R in the computational, analytics, and data science areas has led to some innovative techniques in recent years for interactive analytics. This rate of change presents challenges for IT organizations to keep up and to …