Novartis

An R package for Data Science and Deep Visualization of a complex clinical database

We define and illustrate a "deep visualization" paradigm for the analysis of a relatively large and complex clinical database for psoriasis (PSO) and psoriatic arthritis (PsA). This paradigm supports a growing number of machine learning and …

Exploratory Graphics (xGx): Promoting the purposeful exploration of PKPD data

Introduction As pharmacometricians, we sometimes jump into complex modeling before thoroughly exploring our data. This can happen due to tight timelines, lack of ready-to-use graphic tools or enthusiasm for complex models. Exploratory plots can help …

nlmixr: an R package for population PKPD modeling

nlmixr is a free and open source R package for fitting nonlinear pharmacokinetic (PK), pharmacodynamic (PD), joint PK/PD and quantitative systems pharmacology (QSP) mixed-effects models. Currently, nlmixr is capable of fitting both traditional …

ShinyRAP - a framework for analysis and building interactive/dynamic reports using Shiny/Markdown

R has become a prominent data science tool, empowered by a fast-growing modern R eco-system. At Novartis, Shiny and markdown have gained a lot of popularity in analyzing, visualizing and reporting of clinical trial data. Traditional report analysis …